Details

Project TitleHuman Z-alpha1 antitrypsin monoclonal antibody (anti-Z-AT clone 2C1)
Track CodeAB-0200
Websitewww.enterprise.cam.ac.uk
Short Description

Hybridoma cell line producing 2C1 antibodies which detect the abnormal polymeric conformation of human alpha1 antitrysin but not the native monomeric protein. Potentially useful for detecting individuals with antitrypsin deficiency that can lead to cirrhosis of the liver or cancer. Has been used for ELISA & Western Blotting.

AbstractNone
 
Tagsreagent, antibody, hybridoma, cell line
 
Posted DateMar 17, 2011 10:53 AM

Publications

Miranda E, Pérez J, Ekeowa UI, Hadzic N, Kalsheker N, Gooptu B, Portmann B, Belorgey D, Hill M, Chambers S, Teckman J, Alexander GJ, Marciniak SJ, Lomas DA.
A novel monoclonal antibody to characterise pathogenic polymers in liver disease associated with alpha1-antitrypsin deficiency.
Hepatology 2010 Sep; 52(3): 1078-88.
http://onlinelibrary.wiley.com/journal/10.1002/
(ISSN)1527-3350                                                                                                                                   

Ekeowa UI, Freeke J, Miranda E, Gooptu B, Bush MF, Pérez J, Teckman J, Robinson CV, Lomas DA. 
Defining the mechanism of polymerisation in the serpinopathies.
Proc Natl Acad Sci USA 2010 Oct 5; 107(40): 17146-51.
http://www.pnas.org/  

Contact Information

Dr Emma Barker

reagents@enterprise.cam.ac.uk

tel: +44 (0)1223 760339   
Cambridge Enterprise Ltd.              
University of Cambridge           
Hauser Forum                                      
3 Charles Babbage Rd.   
Cambridge                                            
CB3 0GT                                                    
UK                
www.enterprise.cam.ac.uk

Commercialisation

We are seeking to establish non-exclusive relationships.