Project TitleHuman Z-alpha1 antitrypsin monoclonal antibody (anti-Z-AT clone 2C1)
Track CodeAB-0200
Short Description

Hybridoma cell line producing 2C1 antibodies which detect the abnormal polymeric conformation of human alpha1 antitrysin but not the native monomeric protein. Potentially useful for detecting individuals with antitrypsin deficiency that can lead to cirrhosis of the liver or cancer. Has been used for ELISA & Western Blotting.

Tagsreagent, antibody, hybridoma, cell line
Posted DateMar 17, 2011 10:53 AM


Miranda E, Pérez J, Ekeowa UI, Hadzic N, Kalsheker N, Gooptu B, Portmann B, Belorgey D, Hill M, Chambers S, Teckman J, Alexander GJ, Marciniak SJ, Lomas DA.
A novel monoclonal antibody to characterise pathogenic polymers in liver disease associated with alpha1-antitrypsin deficiency.
Hepatology 2010 Sep; 52(3): 1078-88.

Ekeowa UI, Freeke J, Miranda E, Gooptu B, Bush MF, Pérez J, Teckman J, Robinson CV, Lomas DA. 
Defining the mechanism of polymerisation in the serpinopathies.
Proc Natl Acad Sci USA 2010 Oct 5; 107(40): 17146-51.  

Contact Information

Dr Emma Barker

tel: +44 (0)1223 760339   
Cambridge Enterprise Ltd.              
University of Cambridge           
Hauser Forum                                      
3 Charles Babbage Rd.   
CB3 0GT                                                    


We are seeking to establish non-exclusive relationships.